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About the Coss Lab text
About the Coss Lab
The Coss Lab's research goal is to understand how the endocrine cell integrates the panoply of neuroendocrine and peripheral hormonal signals, in addition to metabolic cues and environmental insults, to result in the precise rhythm of synthesis and a delicate balance of hormones that regulate homeostasis.
In particular, the lab is interested to elucidate the regulation of reproductive function and studies the hormones of the hypothalamic-pituitary-gonadal axis and their cross talk with metabolic or inflammatory pathways in regulation of fertility. We aim to uncover fundamental processes controlling pubertal development, reproductive cyclicity in the female, and steroidogenesis and gametogenesis, to better understand disorders that lead to infertility, such as premature ovarian failure and polycystic ovarian syndrome (PCOS), that may lead us to identify prevention and treatment strategies.
We use a variety of in vitro and ex vivo approaches in cell lines and primary cells with integrative genome-wide, biochemical and cell and molecular biology methodologies to understand the regulation of reproductive fitness at the molecular level; and in vivo mouse models, knockouts and wildtypes, at the whole animal level to define the strategies used by the endocrine system to regulate the physiology of the organism.